Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations.

"Declarations Ethics approval and consent to participateThe investigation was carried out under the auspices of the SAL registry and received approval of the Institutional Review Board of the Technical University Dresden (EK 98032010). Written informed consent was obtained from all participants according to the Declaration of Helsinki. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding Open Access funding enabled and organized by Projekt DEAL."

"We analyzed 1583 adult patients with newly diagnosed AML from previous multi-center clinical trials (AML96 [], AML2003 [], AML60+ [], and SORAML []) and the multi-center German Study Alliance Leukemia (SAL) AML registry (NCT03188874). Eligibility was determined by age ≥ 18 years, diagnosis of AML according to WHO criteria [], curative treatment approach with intensive induction therapy and available biomaterial at initial diagnosis. AML without antecedent history of malignancy or radio-/chemotherapy was defined as de novo, while AML not fulfilling these criteria or with prior history of myeloid neoplasms was defined as secondary AML (sAML) and AML with prior radio- and/or chemotherapy for the treatment of non-myeloid malignancies was defined as therapy-associated AML (tAML). Early death (ED30) was defined as death from any cause within 30 days after initial diagnosis. EM AML status was determined at baseline by clinical examination for the entire cohort. Additional histopathologic confirmation of EM in the respective organ was available in 38 cases. The investigation was carried out under the auspices of the SAL registry and received approval of the Institutional Review Board of the Technical University Dresden (EK 98032010). Written informed consent was obtained from all participants according to the Declaration of Helsinki. Declarations: Ethics approval and consent to participateThe investigation was carried out under the auspices of the SAL registry and received approval of the Institutional Review Board of the Technical University Dresden (EK 98032010). Written informed consent was obtained from all participants according to the Declaration of Helsinki.: Consent for publicationNot applicable.: Competing interestsThe authors declare that they have no competing interests. Ethics approval and consent to participate: The investigation was carried out under the auspices of the SAL registry and received approval of the Institutional Review Board of the Technical University Dresden (EK 98032010). Written informed consent was obtained from all participants according to the Declaration of Helsinki."