Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect.

"availability of data and materials not applicable. declarations ethics approval and consent to participate animal experiments were approved by the china animal care and use committee (aup-210320"

"Declarations Ethics approval and consent to participateAnimal experiments were approved by the China Animal Care and Use Committee (Aup-210320-WJG-001-01) and were conducted in accordance with Regulations on the Care and Use of the Laboratory Animal Center of Shenzhen People’s Hospital. Consent for publicationAll authors approved the submission of the manuscript to this journal. Competing interestsThe authors declare no conflicts of interest. Competing interests The authors declare no conflicts of interest."

"Funding This work was supported by the National Key Research and Development Program of China (2020YFA0908000), the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202002), the National Natural Science Foundation of China (82074098, 81841001), and the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZXKT18003)."