Principles and practical applications of structure-based vaccine design.

"Conflict of interest statement P.O.B. and J.S.M. are inventors on U.S. patent application no. 63/032,502 [“Engineered Coronavirus Spike (S) Protein and Methods of Use Thereof”]. J.S.M. is an inventor on U.S. patent application no. 63/089,978 [“Prefusion-stabilized hMPV F Proteins”]. J.S.M. is an inventor on U.S. patent application no. 62/972,886 [“2019-nCoV Vaccine”]. J.S.M. is an inventor on U.S. patent no. 10,960,070 [“Prefusion Coronavirus Spike Proteins and Their Use”]. J.S.M. is an inventor on U.S. patent nos. 9,738,689, 10,017,543, and 11,130,785 [“Prefusion RSV F Proteins and Their Use”]. J.S.M. is an inventor on U.S. patent application no. 62/714,230 [“Nipah virus Immunogens and Their Use”]."

"We thank Ching-Lin Hsieh for helpful discussions during drafting and writing. We also thank Scott Rush and Madeline Sponholtz for a critical reading of the paper. This work was funded in part by 10.13039/100000928Welch Foundation (USA)Grant number F-0003-19620604 (J.S.M.)."