Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integrin α2β1.

"the complete data set for rna-seq results for both cell cultures and glomeruli are provided in the ncbi database ( https://www ncbi nlm nih gov/bioproject/prjna690102 ; accessed 3 november 2021).; data availability statement the complete data set for rna-seq results for both cell cultures and glomeruli are provided in the ncbi database ( https://www ncbi nlm nih gov/bioproject/prjna690102 ). data availability statement the complete data set for rna-seq results for both cell cultures and glomeruli are provided in the ncbi database ( https://www ncbi nlm nih gov/bioproject/prjna690102"

"No conflicts of interest were declared."

"This research was partially conducted at the Integrated Biomedical Imaging Facility at Creighton University, Omaha, NE. This facility is supported by the Creighton University School of Medicine and grants GM103427 and GM139762 from the National Institute of General Medical Science (NIGMS), a component of the National Institutes of Health (NIH). The facility was constructed with support from grants from the National Center for Research Resources (RR016469) and the NIGMS (GM103427). This work was supported by a grant from the NIH (NIH R01 DC015385) to DC and by a gift from Excubio Pharmaceuticals to DC. This investigation is solely the responsibility of the authors and does not necessarily represent the official views of the NIGMS or the NIH."