The impact of sleep disordered breathing on cardiac troponin in acutely decompensated heart failure.

"Declarations Ethics approvalAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in this study. The University of California San Diego Institutional Review Board approved this research. Conflict of interestThe authors declare no competing interests. Conflict of interest The authors declare no competing interests."

"Funding This research is supported by a NIH/NHLBI Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (5 F32 HL 149173–02, PI Light). Drs. Malhotra and Owens are also funded by the NHLBI."

"In this prospective observational study, patients 18–80 years of age and admitted to University of California San Diego Health with a primary diagnosis of ADHF were asked to participate and provide written informed consent. Enrolled subjects then underwent two portable sleep apnea tests (SATs) on hospital nights 1 or 2, and again prior to discharge. Evening and morning serum samples were collected for highly sensitive cardiac troponin T (hs-cTnT) analysis. To date, few have attempted portable SATs on inpatients with decompensated heart failure, and little is known about the degree of overnight troponin change in this population. As such this research was conducted primarily to determine the feasibility of this approach. The University of California, San Diego Human Research Protections Program approved this study. This study was registered on clinicaltrials.gov (NCT03804827)."