Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study.

"Declarations Conflicts of interestAll authors declared having no conflict of interest related to this work. Unrelated potential conflict are as follows: FB received research support from GE Healthcare, Medtronic and Getinge Group, consulting fees from Löwenstein Medical and travel fees from Air Liquide Medical System, which are not related to the present study. LB’s laboratory received research grants from Medtronic and Draeger, equipment from Sentec, Fisher Paykel, Philips and Air Liquide, and lecture fees from Fisher Paykel. Ethics approvalThe study has been independently reviewed and approved by the local Institutional Review Board of each participated centre. Conflicts of interest All authors declared having no conflict of interest related to this work. Unrelated potential conflict are as follows: FB received research support from GE Healthcare, Medtronic and Getinge Group, consulting fees from Löwenstein Medical and travel fees from Air Liquide Medical System, which are not related to the present study. LB’s laboratory received research grants from Medtronic and Draeger, equipment from Sentec, Fisher Paykel, Philips and Air Liquide, and lecture fees from Fisher Paykel."

"Funding Dr. François Beloncle received a grant from IRSR Pays de la Loire for conducting the study in his institute. The sponsor had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Dr Laurent Brochard holds the Keenan Chair in Critical Care and Acute Respiratory Failure."

"This was a prospective, observational, multicentre study (ClinicalTrials.gov NCT02623192). Participating centres are listed in the Supplementary file. The study was approved by research ethics boards from each centre. Informed consent was waived at the centre from Canada since mechanics measurement is a part of the standard of care in patients with moderate and severe ARDS []. In all remaining centres, informed consent was obtained from patient’s substitute decision maker."