Rivaroxaban Underdose for Atrial Fibrillation with Stable Coronary Disease: The AFIRE Trial Findings.

"Conflict of Interest H.A. reports personal fees from Takeda Pharmaceutical, Terumo, Abbott, Otsuka Pharmaceutical, and Bayer Yakuhin. J.Y. reports grants and personal fees from Abbott and Terumo, grants from Boston Scientific and Medtronic, and personal fees from Bristol Myers Squibb and Daiichi-Sankyo. S.Y. reports grants from Takeda Pharmaceutical, Abbott, and Boston Scientific, and personal fees from Daiichi-Sankyo and Bristol Myers Squibb. K.K. reports grants from Grants-in-Aid for Scientific Research (20K08451) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and grants and personal fees from Bayer Yakuhin and Daiichi-Sankyo. T.M. reports grants from the Japan Cardiovascular Research Foundation and personal fees from Nippon Boehringer Ingelheim, Daiichi-Sankyo, AstraZeneca, and Bayer Yakuhin. M.A. reports grants from the Japan Agency for Medical Research and Development (AMED), personal fees from Bristol Myers Squibb and Nippon Boehringer Ingelheim, and grants and personal fees from Bayer Yakuhin and Daiichi-Sankyo. J.A. reports personal fees from Bayer Yakuhin and Sanofi and grants and personal fees from Daiichi-Sankyo. M.N. reports grants and personal fees from Bayer Yakuhin, Daiichi-Sankyo, and Sanofi, and personal fees from Bristol Myers Squibb and Nippon Boehringer Ingelheim. K.M. reports personal fees from Amgen Astellas BioPharma, Astellas Pharma, MSD, Bayer Yakuhin, Sanofi, Takeda Pharmaceutical, Daiichi-Sankyo, Nippon Boehringer Ingelheim, and Bristol Myers Squibb. N.H. reports grants and personal fees from Bayer Yakuhin, grants from Nippon Boehringer Ingelheim, and personal fees from Bristol Myers Squibb. Kimura reports grants from the Japan Cardiovascular Research Foundation, grants and personal fees from Bayer Yakuhin, Daiichi-Sankyo, Sanofi, MSD, and AstraZeneca, and personal fees from Bristol Myers Squibb and Nippon Boehringer Ingelheim. A.H. reports grants and personal fees from Boston Scientific Japan, Otsuka Pharmaceutical, Sanofi, Astellas Pharma, Bristol Myers Squibb, Daiichi-Sankyo, and Bayer Yakuhin, grants from Fukuda Denshi, Abbott Japan, Japan Lifeline, Takeda Pharmaceutical, and Sumitomo Dainippon Pharma, and personal fees from Toa Eiyo, Nippon Boehringer Ingelheim, Amgen Astellas BioPharma, and AstraZeneca. H.O. reports personal fees from Towa Pharmaceutical, Bristol Myers Squibb, Pfizer, Toa Eiyo, Bayer Yakuhin, and Novartis Pharma. The other authors declare that there are no conflicts of interest for this study."

"Funding This work was supported by the Japan Cardiovascular Research Foundation based on a contract with Bayer Yakuhin, Ltd. The study sponsors had no role in the trial design, collection, or analysis of the data, interpretation of the trial results, or writing of the manuscript. "

"Clinical Trial Registration  AFIRE UMIN Clinical Trials Registry ( https://www.umin.ac.jp/ctr/ ), number UMIN000016612, and ClinicalTrials.gov, number NCT02642419. "