Variation in synonymous nucleotide composition among genomes of sarbecoviruses and consequences for the origin of COVID-19.

"it is available in the open science framework platform at https://osf io/rv5u9/ .; the 59 variables were summarised by a pca 3 3 1 the four nucleotide frequencies at third codon-positions are provided in table 2 for the main groups identified in this study (csv file available at https://osf io/rv5u9/ ).; the nucleotide composition was also analysed at four-fold and two-fold degenerate third codon-positions ( table 2 ; csv file available at https://osf io/rv5u9/ ).; for all variables at third codon-positions recsar genomes show intermediate values between scov2rc and scovrc genomes ( table 2 ) 3 2 the dinucleotide frequencies at second and third codon-positions (p23) and at third and first codon-positions (p31) are provided in table 3 (csv files available at https://osf io/rv5u9/ ).; the variables factor map is shown at the bottom left 3 3 the 59 variables corresponding to the relative frequencies between synonymous codons of 18 different amino acids (all except m and w) were summarised in table 4 (csv file available at https://osf io/rv5u9/ ).; all data used for the analyses (multiple genome alignment and csv files used for pcas) are publicly available in the open science framework platform at https://osf io/rv5u9/ . all data used for the analyses (multiple genome alignment and csv table 2 for the main groups identified in this study (csv data availability. all data used for the analyses (multiple genome alignment and csv files used for pcas) are publicly available in the open science framework"

"Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"Data Availability.: All data used for the analyses (multiple genome alignment and csv files used for PCAs) are publicly available in the Open Science Framework platform at https://osf.io/rv5u9/.: Funding: This research was funded by the AAP RA-COVID-19, grant number ANR-21-CO12-0002."