In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed.

"Declarations Competing interestPaul Vulto, Dorota Kurek, Flavio Bonanini, Sara Previdi, Sander de Ruiter, Bart Kramer, Rumaisha Annida, Silvia Bonilla García, Karla Queiroz, Marine Meyer, Maria Clapés Cabrer, Roelof Dinkelberg, Thomas Olivier, Arnaud Nicolas, Karel Domansky, Erik Walinga, Jos Joore, Henriette L. Lanz, Sebastiaan J. Trietsch, and Bob Ronden are employees of Mimetas BV, which is marketing the OrganoPlate Graft and Paul Vulto, Jos Joore, and Sebastiaan J. Trietsch are shareholders of Mimetas BV. OrganoPlate is a registered trademark of Mimetas BV. Hans Clevers is inventor on several patents related to organoid technology; his full disclosure is given at https://www.uu.nl/staff/JCClevers/. Since March 2022, HC is Head of Pharma Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland. The authors have no additional financial interests. Competing interest Paul Vulto, Dorota Kurek, Flavio Bonanini, Sara Previdi, Sander de Ruiter, Bart Kramer, Rumaisha Annida, Silvia Bonilla García, Karla Queiroz, Marine Meyer, Maria Clapés Cabrer, Roelof Dinkelberg, Thomas Olivier, Arnaud Nicolas, Karel Domansky, Erik Walinga, Jos Joore, Henriette L. Lanz, Sebastiaan J. Trietsch, and Bob Ronden are employees of Mimetas BV, which is marketing the OrganoPlate Graft and Paul Vulto, Jos Joore, and Sebastiaan J. Trietsch are shareholders of Mimetas BV. OrganoPlate is a registered trademark of Mimetas BV. Hans Clevers is inventor on several patents related to organoid technology; his full disclosure is given at https://www.uu.nl/staff/JCClevers/. Since March 2022, HC is Head of Pharma Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland. The authors have no additional financial interests."

"We would like to thank Rumaisha Annida and members of the Microscopy CORE Lab of M4I-FHML of Maastricht University for their technical support and Kristin Bircsak for valuable comments. We also would like to thank Mimetas Biocore team including Kristina Bishard, Arthur Stok, Manon Haarmans, and Julia Grasegger This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 848429 and Interreg, project Biomat on microfluidic chip 433. AN and FB have received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 641639 and No 812616, respectively. This project was partly funded by an innovation loan (IK17088) from the Dutch Ministry of Economic Affairs and Climate. This work was supported by partners of Regenerative Medicine Crossing Borders (www.regmedxb.com), powered by Health-Holland, Top Sector Life Sciences & Health."