Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy.

Authors:
Berdowski WM; van der Linde HC; Breur M; Oosterhof N; Beerepoot S and 12 more

Journal:
Acta Neuropathol

Publication Year: 2022

DOI:
10.1007/s00401-022-02440-5

PMCID:
PMC9288387

PMID:
35713703

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Journal Information

Full Title: Acta Neuropathol

Abbreviation: Acta Neuropathol

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Neurology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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Evidence found in paper:

"We thank Inge Huitinga (Netherlands Institute for Neuroscience) and the Netherlands Brain Bank for providing pHrodo-labeled myelin and post-mortem brain tissue of ALSP patients and controls, James M Powers (University of Rochester Medical Center), providing the 4 POLD patients, Harro Seelaar and Shami Melhem (Erasmus MC) for providing post-mortem brain tissue of AD and FTD patients, and Saif Haify for helping with immunohistochemical staining of patient tissue. Funding was provided by two Erasmus University Rotterdam fellowships (TVH). MKN, MB, SB and NIW are members of the European reference network for rare neurological disorders (ERN-RND), project ID 739510."

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Last Updated: Aug 05, 2025