Long-term effects of lower versus higher oxygenation levels in adult ICU patients-A systematic review.

"CONFLICT OF INTEREST Olav Lilleholt Schjørring and Thomas Lass Klitgaard were coordinating investigators of the Handling Oxygenation Targets in the Intensive Care Unit (HOT‐ICU) trial,12 and Frederik Mølgaard Nielsen is the coordinating investigator of the amended trial in COVID‐19 patients (HOT‐COVID).60 Bodil Steen Rasmussen is sponsor and principal investigator of the HOT‐ICU and HOT‐COVID trials. Long‐term outcomes (i.e., cognitive function evaluation and lung function tests) at 1‐year follow‐up are prespecified secondary outcomes in both trials.23, 60, 61 Other authors declare no conflict of interest."

"Funding information Danish Ministry of Higher Education and Science; Novo Nordisk Fonden"

"This systematic review was conducted according to the prespecified and published protocol. We prospectively registered the protocol in the international prospective register of systematic reviews database (PROSPERO) (CRD42021223630), used the methodology of the Cochrane Handbook, and reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) Statement. The PRISMA checklist is available in the Supporting Information Materials . Methods: We included randomised clinical trials (RCTs) comparing lower versus higher oxygen supplementation or oxygenation strategies in adults admitted to the ICU. We searched major electronic databases and trial registers. We included all non‐mortality long‐term outcomes. Prespecified co‐primary outcomes were the long‐term cognitive function measures, the overall score of any valid health‐related quality of life (HRQoL) evaluation, standardised 6‐min walk test, and lung diffusion capacity. The protocol was published and prospectively registered in the PROSPERO database (CRD42021223630)."