Influence of tapentadol and oxycodone on the spinal cord and brain using electrophysiology: a randomized, placebo-controlled trial.

"COMPETING INTERESTS There are no conflicts of interest to declare."

"Funding information Grünenthal GmbH; Kræftens Bekæmpelse"

"The study was carried out at Mech‐Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark. Participants gave written, informed consent before participating in the study and were free to withdraw from the study at any time. The study was approved by The North Denmark Region Committee on Health Research Ethics (N‐20170009) and the Danish Medicines Agency, registered at www.clinicaltrialsregister.eu (EudraCT number: 2017‐000141‐52), monitored by the Good Clinical Practice unit at Aalborg and Aarhus University Hospitals, Denmark, and conducted according to the Declaration of Helsinki. Data in this present study is a subset of a larger study with the main objectives to investigate the effects of tapentadol and oxycodone on the central, autonomic and enteric nervous systems. Other data based on this trial are available in Refs , , , , ."