Effect of asthma management with exhaled nitric oxide <i>versus</i> usual care on perinatal outcomes.

"Conflict of interest: The authors declare no conflict of interest."

"Support statement: Funding was received from the following sources: the National Health and Medical Research Council (NHMRC) of Australia (grant 1060983), University of Newcastle, John Hunter Hospital Charitable Trust, Hunter Medical Research Institute, Singleton Foundation and the Woodend Foundation. V.E. Murphy was the recipient of a NHMRC Career Development Fellowship (grant 1084816) and the Gladys M Brawn Memorial Career Development Fellowship from University of Newcastle. P.G. Gibson is a NHRMC Practitioner Fellow (grant 1155810). The funders played no role in data analysis or interpretation. Funding information for this article has been deposited with the Crossref Funder Registry."

"The Breathing for Life Trial (BLT) was a multicentre, parallel-group randomised controlled trial (RCT) (Australian New Zealand Clinical Trials Registry identifier ACTRN12613000202763) []. Pregnant women were recruited from six Australian public hospital antenatal clinics (7 March 2013 to 11 June 2019). Participants had doctor-diagnosed asthma as used previously in research trials [], symptoms of asthma and/or asthma medication use (prior 12 months), were aged ≥18 years and between 12 and <23 completed weeks’ gestation at randomisation. Exclusion criteria were chronic lung disease other than asthma, use of OCS >14 days in the past 3 months, concomitant chronic illness which may affect participation, inability to perform FENO or spirometry (due to medical contraindication), drug or alcohol dependence or inability to attend regular study visits. All women gave written informed consent prior to participation. Ethics approval was from the Hunter New England Human Research Ethics Committee (HREC; 12/10/17/3.04) and Australian Capital Territory Health HREC (ETH.11.15.232). This trial was prospectively registered at www.anzctr.org.au as ACTRN12613000202763. Deidentified participant data along with a data dictionary will be available after publication. A proposal for how the data would be used would need to be submitted to the corresponding author and approved by the trial executive."