Revisiting the Timeline of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Toward a Temporal Risk Profile.

"Conflicts of Interest The authors have no personal, financial, or institutional conflicts of interest to declare."

"Source of support Open Access funding enabled and organized by Projekt DEAL. No funding bodies had any involvement in the preparation of this trial or in the decision to submit the article for publication."

"This study was designed as an observational cohort analysis and entails a subgroup of data that were partially previously published [, ]. This study was registered (ClinicalTrials.gov identifier NCT02142166) and approved by the Ethics Committee of the Medical Faculty of RWTH Aachen University (EK 062/14). Patients 18 years of age or older with confirmed SAH (either in CT angiography or digital subtraction angiography) who were referred to a single university hospital between 2010 and 2018 were included. Data have been prospectively collected since 2014, and written informed consent was obtained for these patients. Data of patients before 2014 were retrospectively extracted from digital hospital records. Patients with a moribund initial presentation (dilated pupils, other signs of brain stem herniation, or severe dominant hemispheric damage) and anticipated early mortality, SAH due to mycotic or traumatic/pseudoaneurysms, and aneurysms associated with arteriovenous malformations were excluded. Clinical trial registration: The data collection process was part of a previously registered observational study (ClinicalTrials.gov identifier NCT02142166)."