Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.

"Declarations Ethical approval and consent to participateAll animal experiments were performed according to the “Policies on the Use of Animals and Humans in Neuroscience Research” revised and approved by the Society for Neuroscience in 1995, and the Guidelines for the Care and Use of Laboratory Animals of the Ministry of Science and Technology of the People’s Republic of China and the Institutional Animal Care and Use Committee at Tongji Medical College, Huazhong University of Science and Technology approved the study protocol (IACUC Number: 2735). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This study was supported by grants from the Natural Science Foundation of China (91949205, 31730035, 81721005), Science and Technology Committee of China (2016YFC1305800), the Special Project of Technological Innovation of Hubei Province (2018ACA142), and Guangdong Provincial Key S&T Program (2018B030336001)."