A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells.

"analysis code is publicly available at https://github com/blaserlab/hanel_lapo ."

"Declarations Ethics approval and consent to participatePrimary MCL samples were obtained following written informed consent under a protocol approved by the Institutional Review Board of The Ohio State University in accordance with the Declaration of Helsinki. All animal studies were approved by the OSU Institutional Animal Care and Use Committee. Consent for publicationNot applicable. Competing interestsD.H. was an employee of, and stockholder in, Takeda Pharmaceutical Company Limited while engaged in the research project. A.V.D. has received consulting fees from Abbvie, AstraZeneca, BeiGene, Genentech, Pharmacyclics and TG Therapeutics and has ongoing research funding from AstraZeneca, Bayer Oncology, Bristol Meyers Squibb, MEI Pharma, SecuraBio, TG Therapeutics and Takeda Oncology. Competing interests D.H. was an employee of, and stockholder in, Takeda Pharmaceutical Company Limited while engaged in the research project. A.V.D. has received consulting fees from Abbvie, AstraZeneca, BeiGene, Genentech, Pharmacyclics and TG Therapeutics and has ongoing research funding from AstraZeneca, Bayer Oncology, Bristol Meyers Squibb, MEI Pharma, SecuraBio, TG Therapeutics and Takeda Oncology."

"Funding Conquer Cancer Foundation, ASCO Young Investigator Award (2020YIA-6689186701) (WH), OSU K12 Training Grant in Oncology (2K12CA133250-06A1) (WH), Pelotonia Idea Grant (LA), P01 CA214272 (RAB., SC-K, LA), American Brain Tumor Association Basic Research Fellowship sponsored by an Anonymous Corporate Partner (MSS), The Ohio State University Comprehensive Cancer Center/Department of Radiation Oncology start up funds (MKS). Each funding body assisted in the design of the experiments and collection, analysis, and interpretation of the data."