Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study.

"Declarations Conflicts of interestFPW received research funding from Boeringher-Ingelheim, Astrazeneca, Vifor pharmaceuticals, and Whoop, Inc. SH leads a research and training center that receives educational funding from Pfizer Inc. MJM received research funding to her institution from Athersys, Inc, Biomarck Inc, and Quantum Leap Healthcare Collaborative for work unrelated to this manuscript. All other authors have nothing to disclose. Role of the funder/sponsorThe funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Ethics approvalSubjects are enrolled with a waiver of timely informed consent with approval of the institutional review board (IRB) of the University of Pennsylvania (IRB #808542). Subjects or their surrogates are approached as soon as possible for consent, and if consent is not obtained, all biospecimens and data are discarded. Consent to participateSubjects are enrolled with a waiver of timely informed consent with approval of the IRB of the University of Pennsylvania (IRB #808542). Subjects or their surrogates are approached as soon as possible for consent, and if consent is not obtained, all biospecimens and data are discarded. Consent to publishNot applicable/all data used for the present study have been anonymized, and the submission does not include information that may identify individual persons. Conflicts of interest FPW received research funding from Boeringher-Ingelheim, Astrazeneca, Vifor pharmaceuticals, and Whoop, Inc. SH leads a research and training center that receives educational funding from Pfizer Inc. MJM received research funding to her institution from Athersys, Inc, Biomarck Inc, and Quantum Leap Healthcare Collaborative for work unrelated to this manuscript. All other authors have nothing to disclose."

"Funding This study was supported by grants from the NIH (S10OD025172), NIDDK (K08DK124658, R01DK111638, R01DK113191, P30DK079310), NHLBI (R01HL137006, R01HL137915, K24HL155804, R01HL155159), and AHRQ (R01HS027626)."