Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment.

"data are accessible at gene expression omnibus database accession code gse163317.; rna-seq data are accessible at gene expression omnibus database accession gse163317."

"Disclosure of potential conflict of interest: M. Gattorno reports consultancies and speaker’s fee from Novartis and SOBI. S. Volpi, A. Bertoni, F. Penco, P. Bocca, I. Prigione, A. Corcione, and F. Schena report speaker fee from SOBI. The rest of the authors declare that they have no relevant conflicts of interest."

"We thank the patients and their families for their willingness to participate in our study, the service of Immunohematology and Transfusion Medicine of Gaslini Institute for the collection of biological samples, and the Laboratory Core Facility of Gaslini Institute for support for confocal analysis. IRCCS G Gaslini is member of the European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (project ID no. 739543). This work was developed within the framework of the DINOGMI Department of Excellence of MIUR 2018-2022. We thank www.servier.com for the available images. S.V. received financial support from AMRI (Associazione Malattie Reumatiche Infantili)."