High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression.

"Declarations Ethics approval and consent to participateAll animal procedures were reviewed and approved by the Institutional Animal Care and Use Committee of Shanghai Medical College of Fudan University. Consent for publicationNot applicable. Competing interestsThe authors declare no conflict of interest. Competing interests The authors declare no conflict of interest."

"Funding This work was supported by grants from the National Science Foundation of China (81671392 to J.-C.G. and 81871098, 81571361 to H.-G.Z.); Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01), ZJ Lab, and Shanghai Center for Brain Science and Brain-Inspired Technology to J.-C.G.; the Projects of Shanghai Health and Health Committee on Integration of traditional Chinese and Western Medicine (ZY(2018-2020)-FWTX-3007, ZHYY-ZXYJHZX-201915) and Shanghai Municipal Key Clinical Specialty (Geriatrics, No. shslczdzk02802) to H.-G.Z.; Construction of Key Disciplines of Health System in Jing'an District (2021ZD01) to R.-Y.Z."