An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.

"We thank Dr. Daniel Gitler, Ben-Gurion University, Israel for sharing synapsin reagents. We are grateful to the Sheffield Brain Tissue Bank and the very generous individuals who have donated tissue for this research and the next of kin who have accommodated this. The authors thank Steve Mitchell for technical assistance with electron microscopy and the technical and administrative team in SITraN for supporting our work. This work was funded by an Alzheimer’s Research UK project grant (ARUK-PG2019A-008 to KJDV) with additional support from the Medical Research Council (MRC) (MR/S025979/1 and MR/M013251/1 to KJDV) and by Regione Lombardia, Italy, “POR FESR 2014–2020 resources Call HUB Ricerca Innovazione” (CB, FS). EFS was supported by the Motor Neurone Disease Association (DEVOS/APR18/862-791 to KJDV and AJG). RNC was supported by a University of Sheffield Prize studentship. The Y2H screen was funded by the Thierry Latran Foundation (project RoCIP to KJDV and AJG)."