Association of COPD exacerbations and acute cardiovascular events: a systematic review and meta-analysis.

"Competing interests: The authors declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: HM, CN and JM are employees of AstraZeneca and hold stock and/or stock options in the company. EdN and PV are former employees of AstraZeneca. ZM, NP and NE are employees of Maverex Ltd and received funding for their role in conducting the SLR."

"Funding: The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was funded by AstraZeneca."

"This study was conducted in accordance with the Meta-analysis of Observational Studies in Epidemiology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for conducting and reporting systematic reviews. The study protocol was published via PROSPERO: International Prospective Register of Systematic Reviews (#CRD42020211055) and is available at the following link: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020211055. A PRISMA checklist is provided in Supplementary Table S1. We searched for full-text reports containing original data in Ovid MEDLINE, MEDLINE In-Process Citations & Daily Update and EMBASE, and in reference lists of included articles, until 14 May 2021. The detailed search strategy is available in Supplementary Table S2. In addition, reference lists of relevant articles were searched, and systematic reviews were identified by searching the Cochrane Database of Systematic Reviews, Cochrane Library and PROSPERO, to cross-check reference lists. Registration:: The study protocol was published via PROSPERO: International Prospective Register of Systematic Reviews (#CRD42020211055)."