[¹⁸F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice.

"Declarations Ethics approval and consent to participateAll procedures performed in studies involving animals were approved by the University of Pennsylvania Institutional Animal Care and Use Committee (IACUC). All methods were carried out in accordance with relevant guidelines and regulations including Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. This article does not contain any studies with human participants performed by any of the authors. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research was funded by the National Institutes of Health, National Institute of Aging, grant number AG055142, and the National Institute of Neurological Disorders and Stroke grant number NS114656."