Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.

"availability of data and materials the datasets used for the present study are available from the geo depository (accession number gse207251). availability of data and materials the datasets used for the present study are available from the geo depository (accession number gse207251"

"Declaration of Competing Interest Dr. Geschwind has consulted for Adept Field Consulting (Backbay consulting), Ascel Health LLC, Anderson Boutwell Traylor, Best Doctors Inc., Biohaven Pharma Inc., Bioscience Pharma Partners, LLC (BPP), Clarion Consulting, First Thought Consulting, Grand Rounds Inc./UCSF Second Opinion Inc., Maupin Cox Legoy, Quest Diagnostics, Smith & Hennessey LLC and Trinity Partners LLC. He has received speaking honoraria for various medical center lectures, Oakstone Publishing and Wolters Kluwer. He has received past research support from Alliance Biosecure, CurePSP, the Tau Consortium, Quest Diagnostics, and NIH. Dr. Geschwind serves on the board of directors for San Francisco Bay Area Physicians for Social Responsibility and on the editorial board of Dementia & Neuropsychologia."

"Funding This study was supported by the National Institutes of Health grants NS069566 (CJS), NS076896 (CJS), NS047101 (UCSD Microscopy Core), 1S10OD023527 (EM Facility), and AG062429 (UCSD Shiley-Marcos Alzheimer’s Disease Research Center). MDG was funded by the National Institutes of Health grants (AG031189; AG062562; AG055619) and the Michael J. Homer Family Fund. JAL was supported by a Ruth L. Kirschstein Institutional National Research Award from the National Institutes of Health (NS103588)."