Fortified Balanced Energy-Protein Supplementation, Maternal Anemia, and Gestational Weight Gain: A Randomized Controlled Efficacy Trial among Pregnant Women in Rural Burkina Faso.

"Notes: Supported by Bill & Melinda Gates Foundation grant OPP1175213 (to PK). The funder had no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript.: Author disclosures: The authors report no conflicts of interest.: Supplemental Tables 1–3 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/.: Abbreviations used: ANC, antenatal care; BEP, balanced energy-protein; DSMB, Data and Safety Monitoring Board; EAR, Estimated Average Requirement; GA, gestational age; GWG, gestational weight gain; Hb, hemoglobin; IFA, iron–folic acid; INTERGROWTH-21st, International Fetal and Newborn Growth Consortium for the 21st Century; IOM, Institute of Medicine; ITT, intention-to-treat; LMIC, low- and middle-income country; LNS, lipid-based nutrient supplement; MISAME, MIcronutriments pour la SAnté de la Mère et de l'Enfant; MMN, multiple micronutrient; MUAC, midupper arm circumference; pp, percentage point; RCT, randomized controlled trial; SGA, small-for-gestational age; SQ-LNS, small-quantity lipid-based nutrient supplement."

"Notes: Supported by Bill & Melinda Gates Foundation grant OPP1175213 (to PK). The funder had no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript.: Author disclosures: The authors report no conflicts of interest.: Supplemental Tables 1–3 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/.: Abbreviations used: ANC, antenatal care; BEP, balanced energy-protein; DSMB, Data and Safety Monitoring Board; EAR, Estimated Average Requirement; GA, gestational age; GWG, gestational weight gain; Hb, hemoglobin; IFA, iron–folic acid; INTERGROWTH-21st, International Fetal and Newborn Growth Consortium for the 21st Century; IOM, Institute of Medicine; ITT, intention-to-treat; LMIC, low- and middle-income country; LNS, lipid-based nutrient supplement; MISAME, MIcronutriments pour la SAnté de la Mère et de l'Enfant; MMN, multiple micronutrient; MUAC, midupper arm circumference; pp, percentage point; RCT, randomized controlled trial; SGA, small-for-gestational age; SQ-LNS, small-quantity lipid-based nutrient supplement."

"Conclusions: This trial does not provide evidence that fortified BEP supplementation reduces maternal anemia or increases GWG, as compared with IFA. In conjunction with the small, but positive, effects of maternal BEP supplementation on birth outcomes, our findings warrant the investigation of additional biochemical and postnatal outcomes.: This trial was registered at clinicaltrials.gov as NCT03533712."