High plasma soluble thrombomodulin levels indicated poor prognosis of decompensated liver cirrhosis: a prospective cohort study.

"Conflicts of interest There are no conflicts of interest."

"This study was supported by Capital’s Funds for Health Improvement and Research (No.2020-1-3011) and Reform and development project of Beijing Institute of Hepatology (No. Y-2021KF-1). This study was supported by Capital’s Funds for Health Improvement and Research (No.2020-1-3011) and Reform and development project of Beijing Institute of Hepatology (No. Y-2021KF-1)."

"This was a prospective observational study that was conducted in the future. From August 2016 to February 2021, hospitalized adult patients with decompensated liver cirrhosis were included in the study, with follow-up visits every 6 months or until death or liver transplantation. The study protocol was approved by Beijing Youan Hospital Ethics Committee [NO: 2016-13] in June 2016. All patients provided written informed consent. The research was performed according to the guidelines of the 1975 Declaration of Helsinki (6th revision, 2008). This study protocol was registered in Clinical Trials (ChiCTR1900025035)."