Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission.

Authors:
Daniell H; Nair SK; Guan H; Guo Y; Kulchar RJ and 20 more

Journal:
Biomaterials

Publication Year: 2022

DOI:
10.1016/j.biomaterials.2022.121671

PMCID:
PMC9290430

PMID:
35953331

Journal Information

Full Title: Biomaterials

Abbreviation: Biomaterials

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Biomedical Engineering

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
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Evidence found in paper:

"Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Henry Daniell has patent #USA patent 11,246,819 issued to University of Pennsylvania. Henry Daniell has patent #USA patent 10,806,775 issued to University of Pennsylvania. Henry Daniell has patent #USA patent 10,314,893 issued to University of Pennsylvania."

Evidence found in paper:

"Funding Research in the Daniell laboratory is supported by funding from 10.13039/100000002NIH grant R01 HL 107904, R01 HL 109442, R01 HL 133191. Commonwealth of Pennsylvania, Department of Community and Economic Development grant to HD on “COVID-19 Pennsylvania Discoveries: Responding to SARS-COV-2 Through Innovation & Commercialization” funded purchase of freeze dryers, toxicology studies on ACE2 produced at 10.13039/501100003185Fraunhofer USA/AeroFarms and production of the chewing gum. NP/OP sample collection in the Collman lab is supported by R33-HL137063 and the Penn Center for Coronavirus Research. Microbubbling assay in the Wang laboratory is supported by funding from the Penn Center for Precision Medicine, Penn Health-Tech, Penn Center for Innovation and Precision Dentistry, NIH RADx and BARDA. RAPID assay is supported by the Nemirovsky Prize and the Dean's Innovation Fund from the 10.13039/100007928Perelman School of Medicine at the University of Pennsylvania. Research in Ma laboratory is supported by Taiwan Ministry of Science and Technology (MOST 110-2113-M-001-034-MY3)."

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Paper is freely available to read
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Last Updated: Aug 05, 2025