Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial.

"CONFLICTS OF INTEREST Guarantor of the article: Hirotaka Yamamoto, PhD. Specific author contributions: T. Koyama and H.Y. designed and planned the study. T. Koyama and N.M. collected the data. K.N. performed statistical analysis. T. Koyama and H.Y. prepared the original draft. N.N. and T. Kawai supported editing of the original draft and critically revised the manuscript. All authors approved the final draft. Financial support: This study was partially funded by MIKI Corporation. Potential competing interests: This study was partially funded by MIKI Corporation. N. Nagata and K. Nishiura received a grant from MIKI Corporation. MIKI Corporation has outsourced some of this research to Oneness Support on a fee-for-service basis. N. Miura received a payment from Oneness Support. T. Koyama and H. Yamamoto are employees of MIKI Corporation. The sponsor had no control over the interpretation, writing, publication, or decisions about this work. The other authors declare no conflicts of interest. Ethics: This study was conducted in accordance with the Declaration of Helsinki. Human rights of the subjects were well protected, and the study was conducted with the approval of the institutional review boards of the Miura Clinic (approval number: R2001) and Tokyo Medical University (approval number: T2021-0243). Written informed consent was obtained from all subjects before their enrollment into the study. Clinical Trial Registration: This study was registered at ClinicalTrials.gov (https://www.umin.ac.jp/english/, UMIN 000041384)."

"Financial support: This study was partially funded by MIKI Corporation."