Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration.

"raw data that support the findings of this study are available in the european bioinformatics institute--european nucleotide archive (ebi-ena) under the accession: prjeb54978. data availability all scripts for pre-processing and analyzing the snatac-seq data from psp/cbd frontal cortex and the allen et al bulkrna-seq data from psp tcx are available on github ( https://github com/nes-b/snatac-seq_psp_cbd ). file 2 (pdf 370 kb) supplementary file 3 (xlsx"

"data availability all scripts for pre-processing and analyzing the snatac-seq data from psp/cbd frontal cortex and the allen et al bulkrna-seq data from psp tcx are available on github ( https://github com/nes-b/snatac-seq_psp_cbd )."

"Declarations Conflict of interestThe authors declare that they have no competing interests. Ethics approvalHuman brain tissue samples were collected and provided by the Neurobiobank Munich (NBM) in accordance with Institutional Review Board protocols approved by the Ethics Committee of the LMU Munich (#345-13). Written informed consent was obtained from the donors or their next of kin. Ethical approval for this particular study was also granted by the Ethics Committee of the LMU Munich (#19-442). All procedures were performed in line with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Conflict of interest The authors declare that they have no competing interests."

"Funding Open Access funding enabled and organized by Projekt DEAL. Funding of this project was realized by the Munich Cluster of Systems Neurology (SyNergy), LMU Munich, Munich, Germany. N.B. holds a scholarship from the German Academic Scholarship Foundation, F.L.S.’s research is supported by European Union Marie-Curie Actions (H2020-MSCA-IF-2017: NOJUNKDNA; 792832). K.P. receives funding by the Marie Sklodowska-Curie actions grant, ITN SynDegen (721802). This work was funded by Studienstiftung des Deutschen Volkes and Deutsche Forschungsgemeinschaft (Grant nos. STR 1573/3-1, EXC 2145)."