Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.

"Disclosure statement The authors report no competing interests."

"This work was largely funded by the UK DRI, which receives its funding from the DRI Ltd, funded by the UK Medical Research Council (UKDRI-3003), Alzheimer's Society, and ARUK. JH is supported by the Dolby Foundation, and by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. D.A.S. also received funding from the Alzheimer's Research UK (ARUK) pump priming scheme via the UCL network. VEP is supported by Joint Programming for Neurodegeneration (JPND) - (MRC: MR/T04604X/1). This research has been conducted using the UK Biobank Resource under application number 13310. Matthew Bracher-Smith: Methodology, Formal analysis, Writing – original draft, Writing – review & editing, Visualization. Ganna Leonenko: Formal analysis, Investigation, Data curation. Emily Baker: Formal analysis, Data curation. Karen Crawford: Formal analysis. Andrew C. Graham: Data curation. Dervis A. Salih: Validation, Investigation, Writing – review & editing. Brian W. Howell: Validation, Investigation, Writing – original draft, Writing – review & editing, Visualization. John Hardy: Conceptualization, Validation, Investigation, Writing – original draft, Writing – review & editing, Funding acquisition. Valentina Escott-Price: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Resources, Writing – original draft, Writing – review & editing, Visualization, Supervision, Project administration, Funding acquisition."