Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway.

"the lncrna sequencing data of luad samples have been deposited in the gene expression omnibus (geo) under accession number gse196584."

"Declarations Ethics approval and consent to participateThis study was approved by the Medical Ethics Committee of Affiliated Cancer Hospital of Nanjing Medical University. Animal studies were approved by the Institutional Animal Care and Use Committee of Nanjing Medical University (No. IACUC-2012002). All animal studies were complied with the ARRIVE guidelines and conducted in accordance with the UK Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments, or the National Institutes of Health Guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978). Experiments involving humans were in accordance with the ethical standards of committee (institution and national) and with The Code of Ethics of the World Medical Association (Declaration of Helsinki). All patients completed written informed consent prior to study entry. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This study was supported by the grants from the National Natural Science Foundation of China (Grant Nos. 82073211, 81702892, 82002434, 82003106); The Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Innovation Team (CXTDA2017002); The Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Outstanding Talent (JCRCA2016001); and Young Talents Program of Jiangsu Cancer Hospital (23), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX21-1566)."