Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial.

"Declarations Ethics approval and consent to participateStudies were conducted in compliance with the Declaration of Helsinki, with protocols approved by institutional review boards. Written informed consent was obtained from all patients prior to the initiation of any study-specific procedures. Consent for publicationAll authors confirmed and had consent to publish the manuscript on Journal of Hematology & Oncology. Competing interestsZC, QN, SZ, LM, ML, HW, CY, DY, and YZ: Employees of, and shareholders in, Ascentage Pharma. DY and YZ: Hold positions of leadership within Ascentage. All other authors declare no competing interests. Competing interests ZC, QN, SZ, LM, ML, HW, CY, DY, and YZ: Employees of, and shareholders in, Ascentage Pharma. DY and YZ: Hold positions of leadership within Ascentage. All other authors declare no competing interests."

"Funding This work was supported partially by National Science and Technology Major Project (No. 2018ZX09301021-005), National Key Research and Development Program of China (No. 2017YFA0104500), Innovative Research Groups of the National Natural Science Foundation of China (No. 81621001), Key Program of the National Natural Science Foundation of China (No. 81530046, 81930004), National Nature Science Foundation of China (No. 81770161, No. 81970140), and Ascentage Pharma Group Corp Ltd (Hong Kong)."

"Trial registration : The phase 1 trial is registered at CTR20220566, and the two single-arm, open-label phase 2 studies are registered at ClinicalTrials.gov: NCT03883087 (CML-CP) and NCT03883100 (CML-AP)."