Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease.

"data availability the scrna-seq datasets generated in this study have been deposited to the gene expression omnibus (geo) repository (gse162167).; the scrna-seq datasets from vsmc-lineage-labelled plaque cells from hfd-fed myh11-confetti-apoe animals and the smart-seq2 dataset from healthy myh11-confetti animals are available from geo (gse117963) 13 translational perspective the demonstration that vascular smooth muscle cell (vsmc) oligoclonality arise from activation of proliferation in a small number of vsmcs but that these cells are unlikely to correspond to a dedicated progenitor population has implications for the development of effective treatment strategies in cardiovascular medicine. data availability the scrna-seq datasets generated in this study have been deposited to the gene expression omnibus (geo) repository (gse162167"

"Conflict of interest: M.S. is a co-founder of Enhanc3D Genomics Ltd. H.F.J is a key opinion leader for Novo Nordisk."

"Funding This work was supported by a British Heart Foundation (BHF) project grant (PG/19/6/34153), BHF studentships (FS/15/62/32032, FS/15/38/31516), the BBSRC DTP programme, the BHF Centre of Regenerative Medicine (RM/13/3/30159), the BHF Cambridge Centre of Research Excellence (RE/13/6/30180, RE/18/1/34212), and Personal Chair awards from the BHF (CH/20000003, CH/2000003/12800), the NIHR Cambridge Biomedical Research Centre, and the Medical Research Council UK (MRC Investigator funding to M.S., MC-A652-5QA20)."