A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

"COMPETING INTERESTS All authors declared no competing interests for this work."

"Funding information Centre for Human Drug Research (CHDR)"

"This study was performed at the Centre for Human Drug Research, Leiden, the Netherlands in accordance with the Declaration of Helsinki of 1975, as revised in 2013. Approval of the Medical Ethics Committee Stichting Beoordeling Ethiek Biomedisch Onderzoek, Assen, the Netherlands, was obtained prior to study start. The results reported here are part of a larger study that also answered distinctly different objectives: to determine the effects of sleep deprivation on driving performance and to determine the validity of an intra‐epidermal stimulation method. Those results will be or are reported elsewhere. The trial was registered in the Netherlands Trial Register (NTR number NL7517)."