Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans.

"we also uploaded relevant ms/ms spectra including those obtained from the paterno-buchi reaction under the mass spectrometry interactive virtual environment (massive) database under data set msv000090113 (doi:10 25345/c5v97zw46) with a complete list of the spectra that were uploaded in the supplementary materials ."

"Duality of Interest. No potential conflicts of interest relevant to this article were reported."

"Funding. Research in this manuscript was supported by the National Institute of Diabetes and Digestive and Kidney Diseases with K23DK127073 to Z.-Z.C. and R01DK081572 to R.E.G. and J.G.W. The JHS is supported by contracts from the National Heart, Lung, and Blood Institute and the National Institute for Minority Health and Health Disparities and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I/HHSN26800001), and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I, and HHSN268201800012I). MESA and the MESA SNP Health Association Resource (SHARe) projects are conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with MESA investigators. Support for MESA is provided by National Heart, Lung, and Blood Institute contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169, and National Center for Advancing Translational Sciences grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420. WGS for the TOPMed program was supported by the National Heart, Lung and Blood Institute. Centralized read mapping and genotype calling, along with variant quality metrics and filtering, were provided by the TOPMed Informatics Research Center support from National Heart, Lung and Blood Institute (3R01HL117626-02S1, contract HHSN268201800002I) (Broad RNA sequencing, Proteomics HHSN268201600034I, University of Washington RNA sequencing HHSN268201600032I, University of Southern California DNA Methylation HHSN268201600034I, and Broad Metabolomics HHSN268201600038I). Phenotype harmonization, data management, sample-identity QC, and general study coordination were provided by the TOPMed Data Coordinating Center support from National Heart, Lung and Blood Institute (3R01HL-120393, U01HL-120393, contract HHSN268180001I). The provision of genotyping data were supported in part by the National Center for Advancing Translational Sciences, Clinical and Translational Science Institute grant UL1TR001881, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center grant DK063491 to the Southern California Diabetes Endocrinology Research Center. Infrastructure for the CHARGE Consortium is supported in part by the National Heart, Lung, and Blood Institute grant R01HL105756 and also by R01HL151855-01 and the National Institute of Diabetes and Digestive and Kidney Diseases UM1DK078616 contracts."