Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials.

Authors:
Pitcher A; Spata E; Emberson J; Davies K; Halls H and 27 more

Journal:
Lancet

Publication Year: 2022

DOI:
10.1016/S0140-6736(22)01534-3

PMCID:
PMC7613630

PMID:
36049495

Journal Information

Full Title: Lancet

Abbreviation: Lancet

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Medicine

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
Transparency Indicators
Click on green indicators to view evidence text
Core Indicators
Data Sharing
Code Sharing
Evidence found in paper:

"Declaration of interests AP has received grants paid to his institutions from the Marfan Foundation, the British Heart Foundation, the UK National Institute for Health and Care Research Biomedical Research Centre, the Gibson fund, Oxford University Hospitals Charitable Fund, and the Academy of Medical Sciences Clinical Lecturer Starter Grant scheme (which is administered by the Academy on behalf of the Academy, the Wellcome Trust, the UK Medical Research Council [MRC], the British Heart Foundation, Arthritis Research UK, Prostate Cancer UK, and the Royal College of Physicians). CR has received institutional grants from the British Heart Foundation and UK MRC. CBa has received institutional grants from the British Heart Foundation, UK MRC, NIHR, and Boehringer Ingelheim (EMPA-KIDNEY trial)."

Evidence found in paper:

"AcknowledgmentsThe work of the MTT is supported by the Marfan Foundation, the Oxford British Heart Foundation Centre for Research Excellence, and the UK Medical Research Council (MC_UU_00017/4). AP acknowledges funding support from the Marfan Foundation, the British Heart Foundation, including from the Oxford British Heart Foundation Centre for Research Excellence (RE/13/1/30181), the UK National Institute for Health and Care Research Biomedical Research Centre, Oxford, the Gibson fund, Oxford University Hospitals Charitable Fund, and from an Academy of Medical Sciences Clinical Lecturer Starter Grant scheme, which is administered by the Academy on behalf of the Academy, the Wellcome Trust, the Medical Research Council, the British Heart Foundation, Arthritis Research UK, Prostate Cancer UK, and the Royal College of Physicians. We would like to thank all the participants who originally took part in the included trials, without whom this research would not have been possible. We would like to thank the clinicians, scientists, and all those who worked on the original trials. JDB would like to thank Laura Muiño Mosquera for her contributions to the Ghent Marfan trial. We would also like to thank Samantha Briggs and Clare Mathews for their valuable administrative assistance in preparing this report."

Protocol Registration
Open Access
Paper is freely available to read
Additional Indicators
Replication
Novelty Statement
Assessment Info

Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025