Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials.

"Declaration of interests JA and DP report receiving a grant to their research institution from Novartis for the ORION 4 trial of inclisiran. AK reports receiving grants for his institution from Abbott, Amgen, and Mylan; consulting fees from AstraZeneca; honoraria from Sanofi and Pfizer; and is a Data Safety Monitoring Board member of the Kowa PROMINENT trial. JS reports receiving grants for his institution from Abbvie, Astra Zeneca, Bayer, Bristol Myers Squibb, Pfizer, and Roche. RC reports a patent for a statin-related myopathy genetic test licensed to University of Oxford from Boston Heart Diagnostics (RC has waived any personal reward). All other authors declare no competing interests."

"AcknowledgmentsThe work of the Cholesterol Treatment Trialists’ Collaboration was funded by the British Heart Foundation (PG/18/16/33570 and CH/1996001/9454), UK Medical Research Council (MC_UU_00017/4), and Australian National Health and Medical Research Council (GNT1037786 and GNT1150467). Although individual trials that were contributing data to the analyses were funded by the pharmaceutical industry, as well as by charities and government organisations, the Cholesterol Treatment Trialists’ Collaboration has not received grant funding from industry. Further details are available at: www.cttcollaboration.org. We thank all participants who originally took part in the included trials, as well as the investigators who conducted those trials, without whom this research would not be possible. We also thank Samantha Briggs and Clare Mathews for their valuable administrative assistance in preparing this report."