Vasodilators for acute heart failure-A protocol for a systematic review of randomized clinical trials with meta-analysis and Trial Sequential Analysis.

"random sequence generation allocation concealment blinding of participants and treatment providers blinding of outcome assessment incomplete outcome data selective outcome reporting for profit bias other risks of bias overall risk of bias these components enable the classification of trials into being at overall "low risk of bias" only if all bias domains is classified as "low risk of bias" a trial will be classified as overall "high risk of bias" if at least one of the bias domains are classified as "unclear" or "high risk of bias" we will also evaluate for "profit bias" as specified in data s1 .; data s1 supporting information."

"This work was supported by a research grant from the Danish Cardiovascular Academy (grant no. CPD5Y‐2022002‐HF), funded by the Novo Nordisk Foundation (grant no. NNF20SA0067242) and The Danish Heart Foundation. The authors declare no conflict of interest."

"Funding information The Danish Heart Foundation, Grant/Award Number: CPD5Y‐2022002‐HF; Novo Nordisk Foundation, Grant/Award Number: NNF20SA0067242"