An approach to assess and adjust for the influence of multicollinear covariates on metabolomics association patterns-applied to a study of the associations between a comprehensive lipoprotein profile and the homeostatic model assessment of insulin resistance.

"Declarations Conflict of interestThe authors declare no conflict of interest. Ethical approval and consent to participateOur procedures and methods conform to ethical guidelines defined by the World Medical Association’s Declaration of Helsinki and its subsequent revisions. The South-East Regional Committee for Medical Research Ethics in Norway approved the ASK study protocol (reference number 2013/1893). Prior to all testing, we obtained written informed consent from each child’s parents or legal guardian and from the responsible school authorities. The ASK study is registered in Clinicaltrials.gov with identification number: NCT02132494. Conflict of interest The authors declare no conflict of interest."

"Funding Open access funding provided by University of Bergen (incl Haukeland University Hospital). The ASK study was supported by the Research Council of Norway [#221047/F40]; and the Gjensidige Foundation [#1042294]."

"Declarations: Conflict of interestThe authors declare no conflict of interest.: Ethical approval and consent to participateOur procedures and methods conform to ethical guidelines defined by the World Medical Association’s Declaration of Helsinki and its subsequent revisions. The South-East Regional Committee for Medical Research Ethics in Norway approved the ASK study protocol (reference number 2013/1893). Prior to all testing, we obtained written informed consent from each child’s parents or legal guardian and from the responsible school authorities. The ASK study is registered in Clinicaltrials.gov with identification number: NCT02132494. Ethical approval and consent to participate: Our procedures and methods conform to ethical guidelines defined by the World Medical Association’s Declaration of Helsinki and its subsequent revisions. The South-East Regional Committee for Medical Research Ethics in Norway approved the ASK study protocol (reference number 2013/1893). Prior to all testing, we obtained written informed consent from each child’s parents or legal guardian and from the responsible school authorities. The ASK study is registered in Clinicaltrials.gov with identification number: NCT02132494."