Mid-regional plasma pro-atrial natriuretic peptide and stroke volume responsiveness for detecting deviations in central blood volume following major abdominal surgery.

"This study was supported by the Lundbeck Fonden (R230‐2016‐2727, DK), Ehrenreich's Fond (DK), Gangstedfonden (A31738, DK), Rigshospitalet's Fond (DK), and J.E. and G. Ormstrup's Fond (DK). The authors declare no conflict of interest."

"Funding information Gangstedfonden, Grant/Award Number: A31738 DK; Grosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs Fond; J.E. and G. Ormstrup's Fond; Lundbeckfonden, Grant/Award Number: R230‐2016‐2727 DK; Rigshospitalet"

"This prospective cohort study was conducted at a single tertiary referral center (2015–2016) as approved by the Scientific‐Ethical Committees, Kongens Vænge 2, 3400 Hillerød, Capital Region, Copenhagen (ID: H‐3‐2014‐021, approved August 26, 2015), The Danish Data Protection Agency (ID: RH‐2015‐232) and registered at Clinicaltrials.gov (ID: NCT02507414). The study was conducted with patients who were simultaneously enrolled in another prospective, observational trial which was registered under the same clinical trial ID. Predefined outcomes were: deviations in plasma MR‐proANP and the SV response to HDT (primary) and the applied crystalloid/colloid ratio, fluid balance, as postoperative complications (secondary outcomes). Also, a post hoc variable was defined to allow for a comparison of fluid balance, crystalloid/colloid ratio, and postoperative complications among groups by allocating patients into three percentiles according to their perioperative change in plasma MR‐proANP."