7H-Pyrrolo[2,3-d]pyrimidine-4-amines as Potential Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinases.

"the x-ray crystal structure of p f cdpk4 (4qox from the rscb protein data bank) was used to design inhibitors with a pyrrolo[23- d ]pyrimidine core using schrodinger (2017-4 maestro 11 4) available from the centre for high performance computing (chpc) in south africa."

"Conflict of interest The authors declare no conflict of interest."

"T.D.S. and H.E.C. thank the National Research Foundation (South Africa) for funding. Research reported in this publication was supported by the Medical Research Council (South Africa) under a Self‐Initiated Research Grant and in part by US National Institutes of Health (NIH) grant R21AI123690. The authors acknowledge the Centre for High Performance Computing (CHPC), South Africa, for providing computational resources to this research project."