Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.

"data are available in the following repository https://doi org/10 5281/zenodo 6620797 .; data availability data are available in the following repositories: mri data https://doi org/10 5281/zenodo 6620797 ; motor behavior and mri data - mousebytes + repository https://mousebytes ca/comp-edit? data availability data are available in the following repositories: mri data https://doi"

"Declarations Conflict of interestTJB and LMS have established a series of targeted cognitive tests for animals, administered via touchscreen within a custom environment known as the “Bussey-Saksida touchscreen chamber”. Cambridge Enterprise, the technology transfer office of the University of Cambridge, supported commercialization of the Bussey–Saksida chamber, culminating in a license to Campden Instruments. Any financial compensation received from commercialization of the technology is fully invested in further touchscreen development and/or maintenance. Conflict of interest TJB and LMS have established a series of targeted cognitive tests for animals, administered via touchscreen within a custom environment known as the “Bussey-Saksida touchscreen chamber”. Cambridge Enterprise, the technology transfer office of the University of Cambridge, supported commercialization of the Bussey–Saksida chamber, culminating in a license to Campden Instruments. Any financial compensation received from commercialization of the technology is fully invested in further touchscreen development and/or maintenance."

"Funding REL received fellowship funding from the Alzheimer’s Society of Canada (ASRP Dr. & Mrs. Spatz Doctoral Award). ASdeM received a BrainsCAN Postdoctoral fellowship and a Return Home fellowship from the International Society for Neurochemistry. A.A. received a Post-doctoral fellowship from Parkinson Canada. HS acknowledges support for this study from the Israel Science Foundation grant no. 1016/18 and a PhD fellowship support from Friends of HUJI to NM and The Michael J. Fox Foundation for support to acquire RNA-Seq datasets. EAF is supported by a Canadian Institutes of Health Research (CIHR) Foundation grant (FDN—154301). MAMP, FHB, EAF, VFP, LMS, TJB, MC, WYC, and CSP received support from the Canadian Institutes of Health Research (CIHR, PJT 162431, PJT 159781, PJT-169101), Natural Science and Engineering Research Council of Canada (402524-2013 RGPIN; 03592-2021 RGPIN; 06711–2019 RGPIN), The Tanenbaum Open Science Institute (TOSI), and a BrainsCAN/Healthy Brains for Healthy Lives (Canada First Research Excellence Fund to Western/McGill University) Initiative for Translational Neuroscience Award, and BrainsCAN Accelerator Awards, as well as support for the Rodent Cognitive and Innovation Core for behavior experiments. MAMP is a Tier I Canada Research Chair in Neurochemistry of Dementia. LMS is a Tier I Canada Research Chair in Translation Cognitive Neuroscience and a CIFAR Fellow in the Brain, Mind and Consciousness program. TJB is a Western Research Chair. EAF is a Canada Research Chair (Tier 1) in Parkinson’s disease."