The Muscle Protein Synthetic Response to the Ingestion of a Plant-Derived Protein Blend Does Not Differ from an Equivalent Amount of Milk Protein in Healthy Young Males.

"Notes: The project is organized by and executed under the auspices of TiFN (Wageningen, The Netherlands), a public-private partnership on precompetitive research in food and nutrition. Funding for this research was obtained from Tereos (Marckolsheim, France), Cargill (Minneapolis, MN, USA), Kellogg (Battle Creek, MI, USA), and the Top-sector Agri&Food.: Author disclosures: PJMP, IWKK, JMS, LCPGMdG, LBV, TS and LJCvL have the following interests: This study was funded by TiFN, Wageningen, The Netherlands. The sponsors Tereos Syral (Marckolsheim, France), Cargill (Minneapolis, MN, USA), and Kellogg (Battle Creek, MI, USA) partly financed the project. The researchers are responsible for the study design, data collection and analysis, decision to publish, and preparation of the manuscript. The industrial partners have contributed to the project through regular discussion, and were involved in the study design. More specifically: the choice of interventional products which were produced by these sponsors. The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript. In addition: LJCvL and LBV have received research grants, consulting fees, speaking honoraria, or a combination of these from Friesland Campina, Tereos Syral, and Pepsico. The other authors report no conflicts of interest.: The researchers are responsible for the study design, data collection and analysis, decision to publish, and preparation of the manuscript. The industrial partners have contributed to the project through regular discussion, and were involved in the study design, and more specifically in the choice of interventional products which were produced by these partners. The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript.: Supplemental Table 1 and Supplemental Figures 1–3 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/.: Abbreviations used: EAA, essential amino acid; FSR, fractional synthetic rate; GC-IRMS, gas chromatography-combustion-isotope ratio mass spectrometry; iAUC, net incremental area under curve; MILK, 30 g milk protein concentrate; MPE, mole percentage excess; PLANT-BLEND, 15 g wheat protein hydrolysate + 7.5 g corn protein isolate + 7.5 g pea protein concentrate; UNU, United Nations University; UPLC-MS, ultra-performance liquid chromatography-mass spectrometry."

"Notes: The project is organized by and executed under the auspices of TiFN (Wageningen, The Netherlands), a public-private partnership on precompetitive research in food and nutrition. Funding for this research was obtained from Tereos (Marckolsheim, France), Cargill (Minneapolis, MN, USA), Kellogg (Battle Creek, MI, USA), and the Top-sector Agri&Food.: Author disclosures: PJMP, IWKK, JMS, LCPGMdG, LBV, TS and LJCvL have the following interests: This study was funded by TiFN, Wageningen, The Netherlands. The sponsors Tereos Syral (Marckolsheim, France), Cargill (Minneapolis, MN, USA), and Kellogg (Battle Creek, MI, USA) partly financed the project. The researchers are responsible for the study design, data collection and analysis, decision to publish, and preparation of the manuscript. The industrial partners have contributed to the project through regular discussion, and were involved in the study design. More specifically: the choice of interventional products which were produced by these sponsors. The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript. In addition: LJCvL and LBV have received research grants, consulting fees, speaking honoraria, or a combination of these from Friesland Campina, Tereos Syral, and Pepsico. The other authors report no conflicts of interest.: The researchers are responsible for the study design, data collection and analysis, decision to publish, and preparation of the manuscript. The industrial partners have contributed to the project through regular discussion, and were involved in the study design, and more specifically in the choice of interventional products which were produced by these partners. The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript.: Supplemental Table 1 and Supplemental Figures 1–3 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/.: Abbreviations used: EAA, essential amino acid; FSR, fractional synthetic rate; GC-IRMS, gas chromatography-combustion-isotope ratio mass spectrometry; iAUC, net incremental area under curve; MILK, 30 g milk protein concentrate; MPE, mole percentage excess; PLANT-BLEND, 15 g wheat protein hydrolysate + 7.5 g corn protein isolate + 7.5 g pea protein concentrate; UNU, United Nations University; UPLC-MS, ultra-performance liquid chromatography-mass spectrometry."

"Healthy, recreationally active males aged 18–35 y inclusive were eligible to participate in this parallel-group, double-blind, randomized controlled trial (participants’ characteristics are presented in ). Participants were recreationally active and generally performed 2–4 exercise sessions per week in various sports (soccer, basketball, weight lifting, running, cycling, etc.), but were not involved in any structured progressive exercise training regimen. This study was part of a larger trial registered at the Netherlands Trial Register (NTR6548), and was conducted between June 2017 and April 2019 at Maastricht University in Maastricht, The Netherlands (see for the CONSORT flow diagram, indicating the specific comparison that the current study was based on). The data of the milk protein group have been published previously, as well as the procedures applied in this trial (). All participants were informed about the purpose of the study, the experimental procedures, and possible risks before providing written informed consent to participate. The procedures followed were in accordance with the ethical standards of the Medical Ethics Committee of Maastricht University Medical Centre+ (METC 173001), and in accordance with the Helsinki Declaration of 1975 as revised in October 2013. The study was independently monitored and audited by the Clinical Trial Centre Maastricht. Conclusions: Ingestion of 30 g plant-derived protein blend combining wheat-, corn-, and pea-derived protein increases muscle protein synthesis rates in healthy young males. The muscle protein synthetic response to the ingestion of 30 g of this plant-derived protein blend does not differ from the ingestion of an equivalent amount of a high-quality animal-derived protein.: Clinical trial registry number for Nederlands Trial Register: NTR6548 (https://trialsearch.who.int/Trial2.aspx?TrialID=NTR6548)."