Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.

"the broad institute workflows for sample processing and joint variant discovery are publicly available at https://githubcom/gatk-workflows/broad-prod-wgs-germline-snps-indels ."

"Declarations Conflict of InterestR.C.K. is a topic editor for EBSCO Publishing (Dynamed) on movement disorders topics. C. H. G. and R. L. F are founders and scientific advisers of CND Life Sciences, a company that histologically analyzes skin biopsy tissue from neurodegenerative disease patients and produced Fig. 5 in the manuscript. Conflict of Interest R.C.K. is a topic editor for EBSCO Publishing (Dynamed) on movement disorders topics. C. H. G. and R. L. F are founders and scientific advisers of CND Life Sciences, a company that histologically analyzes skin biopsy tissue from neurodegenerative disease patients and produced Fig. 5 in the manuscript."

"Funding A. N. was supported by a Max Kade Fellowship. S. S. was supported by grants from the Parkinson’s Foundation and National Ataxia Foundation. C. G. is supported by a Sudarsky Scholarship from the Division of Movement Disorders at Brigham and Women’s Hospital. Essential grant funding was provided by the Brigham and Women’s Hospital Research Institute (BRI) Director’s Transformative Award, the Barbara Bloom Ranson Fund for Biomarker Discovery in MSA, and NIH grants 1P30AG062421-01 and 1R01NS109209-01A1 (A. T. P., A. S. W., V. K.). V. K. is a New York Stem Cell Foundation Robertson Investigator, a George Cotzias Fellow of the American Parkinson’s Disease Association (APDA), recipient of the 2018 Bishop Dr. Karl Golser Award, and a co-founder of Yumanity Therapeutics and DaCapo Brainscience. T. S. reports receiving research grants from Sanofi-Genzyme and Novartis Pharmaceuticals and research funding from the US Government Department of Defense, National Multiple Sclerosis Society, Nancy Davis Foundation’s “Race to Erase MS” program, Harvard Neuro-Discovery Center, Ann Romney Center for Neurologic Diseases, and Water Cove Charitable Foundation. E. R. reports receiving a research fellowship grant from Sigrid Jusélius Foundation. S. W. S. was supported in part by NIH grant 1ZIANS003154. A. S. G. was supported by Massachusetts Life Sciences Center, R01NS117826, and Biogen Inc. to create and install Neurobooth at Massachusetts General Hospital. D. V. serves as founder of Talerics Consulting, LLC. L. R. K., C. B. L., P. G. B., and V. K. are members of the Board of Directors of the Multiple System Atrophy Coalition. The remaining authors did not receive support from any organization for the submitted work."