Human papillomavirus-related neoplasia of the ocular adnexa.

"Special thanks also go to my co‐supervisor, Peter Bjerre Toft. Thank you for taking me under your wing and for your ever valuable feedback, advice, and support. You have always been a great inspiration to me, and I thank you for motivating me to choose the field of ophthalmology. Thanks to co‐supervisor Mikkel Funding for your help and valuable feedback. These studies would not have been possible without funding from the Svend Helge Arvid Schrøder and Ketty Lydia Larsen Shrøder Foundation, Denmark; the Synoptik Foundation, Denmark; “Fight for Sight, Denmark”, the Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Copenhagen University Hospital, Rigshospitalet, Denmark; and the Danish Eye Research Foundation. Thank you! Co‐supervisor: Mikkel Funding, MD, PhD. Department of Ophthalmology, Aarhus University Hospital Skejby, Denmark, and Department of Clinical Medicine, Aarhus University. This thesis is based on the following papers, which will be referred to in the text using the following Roman numerals: Ramberg I, Toft PB, Georgsen JB, Siersma VD, Funding M, Jensen DH, von Buchwald C, Heegaard S. Conjunctival Intraepithelial Neoplasia and Carcinoma: Distinct Clinical and Histopathological Features in Relation to Human Papillomavirus Status. Br J Ophthalmol. 2021. 105:878–883.Ramberg I, Vieira FG, Toft PB, von Buchwald C, Funding M, Nielsen FC, Heegaard S. Genomic Alterations in Human Papillomavirus Positive and ‐Negative Conjunctival Squamous Cell Carcinoma. IOVS. 2021.Ramberg I, Vieira FG, Toft PB, von Buchwald C, Heegaard S. Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System. Cancers. 2022. 14:2558.Ramberg I and Heegaard S. Human Papillomavirus Related Neoplasia of the Ocular Adnexa. Viruses. 2021. 13:1522. List of scientific papers not included in this thesis, but with relevance to the subject: Ramberg I, Møller‐Hansen M, Toft PB, Funding M, Heegaard S. Human Papillomavirus Infection Plays a Role in Conjunctival Squamous Cell Carcinoma: A Systematic Review and Meta‐analysis of Observational Studies. Acta Ophthalmol. 2020. 99:478–488.Ramberg I, Toft PB, Heegaard S. Carcinomas of the Lacrimal Drainage System. Surv Ophthalmol. 2020. 65:691–707.Ramberg I, Heegaard S, Prause JU, Sjö NC, Toft PB. Squamous Cell Dysplasia and Carcinoma of the Conjunctiva. A Nationwide, Retrospective, Epidemiological Study of Danish Patients. Acta Ophthalmol. 2015. 93:663–6.Ramberg I, Sjö NC, Bonde JH, Heegaard S. Inverted Papilloma of the Conjunctiva. BMJ Open Ophthalmol. 2019. 28:e000193.Fagerberg PS, Ramberg I, Toft PB. Combining Brachytherapy and Cryotherapy as Adjuvant Therapy for Squamous Cell Carcinoma of the Conjunctiva: Literature Review and Case Reports. Ocul Oncol Pathol. 2021. 7:77–84.Henriksen JR, Ramberg I, Mikkelsen LH, Heegaard S. The Role of Infectious Agents in Cancer of the Ocular Region. APMIS. 2020. 128:136–149. "