Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Na<sub>v</sub>1.5 downregulation and ventricular arrhythmias.

Authors:
Hu CC; Wei X; Liu JM; Han LL; Xia CK and 9 more

Journal:
Mil Med Res

Publication Year: 2022

DOI:
10.1186/s40779-022-00415-x

PMCID:
PMC9563440

PMID:
36229865

Journal Information

Full Title: Mil Med Res

Abbreviation: Mil Med Res

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Military Medicine

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
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Evidence found in paper:

"Declarations Ethics approval and consent to participateAll animal experiments were approved by the Institutional Animal Use and Care Committee at Tongji Medical College, Huazhong University of Science and Technology ([2022] IACUC Number: 2853). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

Evidence found in paper:

"Funding This work was supported by grants from the National Natural Science Foundation of China (81770824, 81270239)."

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Open Access
Paper is freely available to read
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Tool: rtransparent

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Last Updated: Aug 05, 2025