Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone.

"availability of data and materials the data underlying this article are available through open science framework at https://dx doi org/10 17605/osf io/v7cn8 . table 3 a-c raw data availability of data and materials the data underlying this article are available through open science framework"

"Declarations Ethics approval and consent to participateAll participants provided either verbal or written informed consent for all study procedures. The University of Pennsylvania’s institutional review board approved all research activities. Consent for publicationNot applicable. Competing interestsCNE has served on advisory boards for Asarina Pharma and Sage Therapeutics and has been a consultant and received grant support from Sage Therapeutics. ALM is a consultant for Sage Therapeutics and Pure Tech health. ALM holds a provisional patent on the anti-inflammatory actions of allopregnanolone and related steroids on toll-like receptor pathways in the immune system and brain.AMN, KAD, RLJ, MDS, WC, MS, AAS, AK, and JL reported no biomedical interested or potential conflicts of interest. Competing interests CNE has served on advisory boards for Asarina Pharma and Sage Therapeutics and has been a consultant and received grant support from Sage Therapeutics. ALM is a consultant for Sage Therapeutics and Pure Tech health. ALM holds a provisional patent on the anti-inflammatory actions of allopregnanolone and related steroids on toll-like receptor pathways in the immune system and brain. AMN, KAD, RLJ, MDS, WC, MS, AAS, AK, and JL reported no biomedical interested or potential conflicts of interest."

"Funding This work was supported by the National Institutes of Health grants R01DA036289 (CNE) and U54AG062319 (AMN; PI Wendy Kohrt) as well as funding from the Ludeman Center for Women's Health Research, University of Colorado (AMN). Fig 1 was designed with biorender.com."

"Trial registration Clinicaltrials.gov registration, retrospectively registered: NCT01954966; https://clinicaltrials.gov/ct2/show/NCT01954966 \"