Advances and challenges in using nirmatrelvir and its derivatives against SARS-CoV-2 infection.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This study was supported by the Qingdao Major Scientific and Technological Project for Distinguished Scholars (Project No.: 20170103), the Laoshan Major Scientific and Technological Project for Distinguished Scholars (Project No.: 20181030), the 10.13039/501100007129Natural Science Foundation of Shandong Province (Project No.: ZR2020MH369), the Hospital Pharmacy Research Foundation of Guangdong Province (Project No.: 2022A01), and the Science and Technology Planning Project in Zhuhai (Project No.: ZH2202200090HJL). Wujun Chen: Writing - Original draft preparation, Supervision, Supervision; Bing Liang: Writing - Original draft preparation, Resources; Xiaolin Wu: Formal analysis, Investigation; Ling Li: Formal analysis, Investigation, Funding acquisition; Chao Wang: Writing - Reviewing and Editing, Project administration; Dongming Xing: Conceptualization, Writing - Reviewing and Editing, Project administration, Funding acquisition."