Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis.

"availability of data and materials the rna sequencing data from this study have been deposited in the ncbi sequence read archive (sra) database under the accession number: prjna854306.; metabolomics data from this study have been deposited to the embl-ebi metabolights database (doi: 10 1093/nar/gkz1019 pmid:31691833) with the identifier mtbls5276.; the complete dataset can be accessed here https://www ebi ac uk/metabolights/mtbls5276 . table s4 sirna sequence additional file 2 . raw data availability of data and materials the rna sequencing data from this study have been deposited in the ncbi sequence read archive (sra) database under the accession number: prjna854306"

"Declarations Ethics approval and consent to participateThe “Guide for the Care and Use of the Laboratory Animals” published by the National Institutes of Health (NIH) was followed in all animal studies. The animal experiments were conducted with the approval of the Institutional Animal Care and Use Committee at Nanjing University (SCXK-Jiangsu-2019-0056). All patients gave their written, informed consent. The ethics committee of Medical School of Nanjing University has given its approval to all experiments involving human samples. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no conflict of interest. Competing interests The authors declare that they have no conflict of interest."

"Funding This work was supported by grants from National Natural Science Foundation of China (82273011, 82072648 and 81772542), the Natural Science Foundation of Jiangsu Province (BK20211508), the Fundamental Research Funds for the Central Universities (021414380500), Nanjing Medical Science and Technique Development Foundation (JQX21009)."