Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial.

"Declarations Conflicts of interestAll authors reported no possible competing interests. Conflicts of interest All authors reported no possible competing interests."

"Funding This project has received funding from the Dutch Organization for Health Research and Development ZonMw (Grant 848017008), Stichting de Merel and Erasmus MC MRace Grant. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report."

"The DOLPHIN multicentre, open-label, RCT was performed in ICUs at eight academic and teaching hospitals in the Netherlands. The trial design has been published before and is available in the trial protocol []. This trial was conducted between October 2018 and September 2021. Medical ethical board approval was obtained at the Erasmus University Medical Center (Erasmus MC) (MEC-2017-568; EudraCT 2017-004677-14). Additionally, the medical ethical board of each study site approved the protocol. All patients or their legal representatives provided written informed consent before randomisation."