Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers' Fear of Hypoglycemia and Improves Their Well-Being.

"Duality of Interest. M.E.W. is a consultant at CamDiab, Ltd., and reports patents related to closed loop. C.d.B. has received speaker honoraria from MiniMed Medtronic and has been a member of its European Psychology and e-Learning Advisory Boards. U.S. has received speaker honoraria from MiniMed Medtronic. E.F.-R. reports having received speaker honoraria from MiniMed Medtronic and Eli Lilly and serving on advisory boards for Eli Lilly. J.K.M. is a shareholder in Decide Clinical Software, Ltd.; a member of the advisory boards of Boehringer Ingelheim, Eli Lilly, Medtronic, Prediktor AS, Roche Diabetes Care, and Sanofi; and has received speaker honoraria from Abbott Diabetes Care, AstraZeneca, Dexcom, Eli Lilly, NovoNordisk AS, Roche Diabetes Care, Servier, and Takeda. T.M.K. has received speaker honoraria from MiniMed Medtronic, Roche, and Eli Lilly and consulted for Sanofi-Aventis. B.R.-M. reports having received speaker honoraria from Abbott, MiniMed Medtronic, Eli Lilly, Roche, Menarini, and Novo Nordisk and serving on advisory boards for Eli Lilly. S.E.H. declares speaker honoraria from Eli Lilly, Sanofi, Pfizer, Vertex, Medtronic, and Omnipod/Insulet. F.M.C. has received speaking fees from Abbott, Medtronic, Eli Lilly, and Novo Nordisk. C.B. reports receiving grant support from Tandem Diabetes Care and consulting for CamDiab, Ltd. J.W. reports receiving speaker honoraria from Ypsomed. R.H. reports receiving speaker honoraria from Eli Lilly, Dexcom, and Novo Nordisk; receiving license and/or consultancy fees from B. Braun and Abbott Diabetes Care; holding patents related to closed loop; and being a director at CamDiab, Ltd. No other potential conflicts of interest relevant to this article were reported."

"Funding. This work was funded by the European Commission within the Horizon 2020 Framework Programme under grant 731560. Additional support for the artificial pancreas work was provided by the National Institute for Health Research Cambridge Biomedical Research Centre, JDRF, and the Wellcome Strategic Award (100574/Z/12/Z). Dexcom supplied discounted continuous glucose monitoring devices."